Map of US highway 65 and family, with US 218 and US 425
US 65 is represented by the purple line running from Albert Lea MN to Clayton LA. The red lines extending north and south of those points are the historic extents of US 65. The dashed red line north of Minneapolis represents a possible one-year extension of the route.
US 165 is the blue line from Little Rock AR to Iowa LA.
US 218 is also shown on this map: the blue line beginning in Keokuk IA. Its current northern terminus is in Owatonna MN; the red line extending north from there to St. Paul is the historic extent of US 218. This is a north/south branch route misnumbered as if it runs east/west, so I included it on this map to demonstrate how the highway would fit into the US 65 family, if it were to be assigned a number US x65. In fact, some early Minnesota planning maps showed this route as "US 265". That was the only number that would've worked in 1926, when the US routes were originally commissioned, but by the late 1930s it could've also be numbered as a branch of US 61 or US 63. You can also view the US 18 map, which shows US 218 with its implied family.
US 425 is also shown on this map (the green line from Pine Bluff AR to Natchez MS). Because its number is a major violation of US route numbering conventions, I included it on this map to demonstrate how the highway would fit into the US 65 family, if it were to be assigned a number US x65.